Epidemiology of Frontotemporal Lobar Degeneration in Northern Finland

Background: Frontotemporal lobar degeneration (FTLD) is responsible for as many as every fifth case of early-onset dementia. Very few epidemiological studies of FTLD have been conducted; there are no published epidemiological data of FTLD from Finland or the other Nordic countries. The C9ORF72 expan...

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Bibliographic Details
Published in:Dementia and Geriatric Cognitive Disorders Extra
Main Authors: Laura Luukkainen, Risto Bloigu, Virpi Moilanen, Anne Marja Remes
Format: Article in Journal/Newspaper
Language:English
Published: Karger Publishers 2015
Subjects:
Frontotemporal dementia
Progressive nonfluent aphasia
Epidemiology
Semantic dementia
Incidence
Behavioral variant
Prevalence
Neurology. Diseases of the nervous system
RC346-429
Geriatrics
RC952-954.6
Northern Finland
Online Access:https://doi.org/10.1159/000440858
https://doaj.org/article/f20f2796f9234ed6bc0615c3648b8b1e
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Summary:Background: Frontotemporal lobar degeneration (FTLD) is responsible for as many as every fifth case of early-onset dementia. Very few epidemiological studies of FTLD have been conducted; there are no published epidemiological data of FTLD from Finland or the other Nordic countries. The C9ORF72 expansion-associated FTLD is common in Finland; thus, the prevalence of FTLD is expected to be high in this population. Methods: We retrospectively evaluated the incidence and prevalence of FTLD in university hospital settings in Northern Finland. Results: The mean 1-year incidence of FTLD was 5.54/100,000 (range 1.9-11.3/100,000) in the population aged 45-65 years. The prevalence of FTLD in the same age group was 20.5/100,000. Conclusion: The incidence and prevalence of FTLD in Finland seem to be the highest in Europe. However, studies from different countries may not be directly mutually comparable due to methodological issues.

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