Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg)
A previous seroepidemiological study in the rural zone of Vargem Alta (ES) SouthEast of Brazil, showed a prevalence of up to 9% of hepatitis B surface antigen (HBsAg) in some areas. One hundred susceptible children aging 1 to 5 years old were selected and immunized with a recombinant DNA hepatitis B...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1993
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Online Access: | https://doi.org/10.1590/S0036-46651993000100013 https://doaj.org/article/f0803941c706410a8a17971653cf7e13 |
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ftdoajarticles:oai:doaj.org/article:f0803941c706410a8a17971653cf7e13 2024-09-09T19:28:37+00:00 Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg) C.R.B. Ferreira C.F.T. Yoshida L.A.C. Mercadante D.F. Gomes J.M. Oliveira M.S. França M. Sidoni I.C. Ennes M.L. Baptista H.G. Schatzmayr A.M.C. Gaspar 1993-02-01T00:00:00Z https://doi.org/10.1590/S0036-46651993000100013 https://doaj.org/article/f0803941c706410a8a17971653cf7e13 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651993000100013 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651993000100013 0036-4665 1678-9946 https://doaj.org/article/f0803941c706410a8a17971653cf7e13 Revista do Instituto de Medicina Tropical de São Paulo, Vol 35, Iss 1, Pp 89-92 (1993) DNA recombinant vaccine Immune response-children hepatitis B recombinant vaccine Anti-HBs Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1993 ftdoajarticles https://doi.org/10.1590/S0036-46651993000100013 2024-08-05T17:49:30Z A previous seroepidemiological study in the rural zone of Vargem Alta (ES) SouthEast of Brazil, showed a prevalence of up to 9% of hepatitis B surface antigen (HBsAg) in some areas. One hundred susceptible children aging 1 to 5 years old were selected and immunized with a recombinant DNA hepatitis B vaccine (Smith-Kline 20 mcg) using the 0-1-6 months vaccination schedule. Blood samples were collected at the time of the first vaccine dose (month 0) in order to confirm susceptible individuals and 1,3,6 and 8 months after the first dose , to evaluate the antibody response. Our results showed that two and five months after the second dose, 79% and 88% of children seroconverted respectively, reaching 97% after the third dose. The levels of anti-HBs were calculated in milli International Units/ml (mIU/ml) and demonstrated the markedly increase of protective levels of antibodies after the third dose. These data showed a good immunogenicity of the DNA recombinant hepatitis B vaccine when administered in children of endemic areas. Um estudo soroepidemiológico prévio na zona rural de Vargem Alta (ES) - Sudeste do Brasil, mostrou uma predominância de até 9% do antígeno de superfície da Hepatite B (HBsAg). Foram selecionadas 100 crianças com faixa etária entre 1 e 5 anos de idade, as quais foram imunizadas com vacina contra Hepatite B -DNA recombinante (Smith-Kline,20 mcg) nos meses 0,1 e 6. Foram coletadas amostras de sangue antes da primeira dose da vacina (mês 0) para confirmação dos susceptíveis, e nos meses 1,3,6 e 8 após a vacinação para avaliação da resposta vacinai. Os resultados mostraram que 79 e 88% das crianças apresentaram soroconversão dois e cinco meses após a segunda dose respectivamente, atingindo 97% de soroconversão, após a 3a.dose. Os níveis de anti-HBs foram calculados em miliunidades internacionais/ml (mUI/ml), demonstrando um considerável aumento dos níveis de anticorpos protetores após a 3a. dose. Os resultados demonstraram uma boa imunogenicidade da vacina de DNA recombinante contra hepatite B, ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Alta Arctic Boa ENVELOPE(15.532,15.532,66.822,66.822) Sudeste ENVELOPE(-60.516,-60.516,-62.988,-62.988) Revista do Instituto de Medicina Tropical de São Paulo 35 1 89 92 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
DNA recombinant vaccine Immune response-children hepatitis B recombinant vaccine Anti-HBs Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
DNA recombinant vaccine Immune response-children hepatitis B recombinant vaccine Anti-HBs Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 C.R.B. Ferreira C.F.T. Yoshida L.A.C. Mercadante D.F. Gomes J.M. Oliveira M.S. França M. Sidoni I.C. Ennes M.L. Baptista H.G. Schatzmayr A.M.C. Gaspar Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg) |
topic_facet |
DNA recombinant vaccine Immune response-children hepatitis B recombinant vaccine Anti-HBs Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A previous seroepidemiological study in the rural zone of Vargem Alta (ES) SouthEast of Brazil, showed a prevalence of up to 9% of hepatitis B surface antigen (HBsAg) in some areas. One hundred susceptible children aging 1 to 5 years old were selected and immunized with a recombinant DNA hepatitis B vaccine (Smith-Kline 20 mcg) using the 0-1-6 months vaccination schedule. Blood samples were collected at the time of the first vaccine dose (month 0) in order to confirm susceptible individuals and 1,3,6 and 8 months after the first dose , to evaluate the antibody response. Our results showed that two and five months after the second dose, 79% and 88% of children seroconverted respectively, reaching 97% after the third dose. The levels of anti-HBs were calculated in milli International Units/ml (mIU/ml) and demonstrated the markedly increase of protective levels of antibodies after the third dose. These data showed a good immunogenicity of the DNA recombinant hepatitis B vaccine when administered in children of endemic areas. Um estudo soroepidemiológico prévio na zona rural de Vargem Alta (ES) - Sudeste do Brasil, mostrou uma predominância de até 9% do antígeno de superfície da Hepatite B (HBsAg). Foram selecionadas 100 crianças com faixa etária entre 1 e 5 anos de idade, as quais foram imunizadas com vacina contra Hepatite B -DNA recombinante (Smith-Kline,20 mcg) nos meses 0,1 e 6. Foram coletadas amostras de sangue antes da primeira dose da vacina (mês 0) para confirmação dos susceptíveis, e nos meses 1,3,6 e 8 após a vacinação para avaliação da resposta vacinai. Os resultados mostraram que 79 e 88% das crianças apresentaram soroconversão dois e cinco meses após a segunda dose respectivamente, atingindo 97% de soroconversão, após a 3a.dose. Os níveis de anti-HBs foram calculados em miliunidades internacionais/ml (mUI/ml), demonstrando um considerável aumento dos níveis de anticorpos protetores após a 3a. dose. Os resultados demonstraram uma boa imunogenicidade da vacina de DNA recombinante contra hepatite B, ... |
format |
Article in Journal/Newspaper |
author |
C.R.B. Ferreira C.F.T. Yoshida L.A.C. Mercadante D.F. Gomes J.M. Oliveira M.S. França M. Sidoni I.C. Ennes M.L. Baptista H.G. Schatzmayr A.M.C. Gaspar |
author_facet |
C.R.B. Ferreira C.F.T. Yoshida L.A.C. Mercadante D.F. Gomes J.M. Oliveira M.S. França M. Sidoni I.C. Ennes M.L. Baptista H.G. Schatzmayr A.M.C. Gaspar |
author_sort |
C.R.B. Ferreira |
title |
Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg) |
title_short |
Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg) |
title_full |
Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg) |
title_fullStr |
Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg) |
title_full_unstemmed |
Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg) |
title_sort |
immunization aganist hepatitis b in children from endemic zone: evaluation of the antibody response against the dna recombinant vaccine (engerix b-20 mcg) imunização contra hepatite b em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina hb recombinante (engerix b-20mcg) |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1993 |
url |
https://doi.org/10.1590/S0036-46651993000100013 https://doaj.org/article/f0803941c706410a8a17971653cf7e13 |
long_lat |
ENVELOPE(15.532,15.532,66.822,66.822) ENVELOPE(-60.516,-60.516,-62.988,-62.988) |
geographic |
Alta Arctic Boa Sudeste |
geographic_facet |
Alta Arctic Boa Sudeste |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 35, Iss 1, Pp 89-92 (1993) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651993000100013 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651993000100013 0036-4665 1678-9946 https://doaj.org/article/f0803941c706410a8a17971653cf7e13 |
op_doi |
https://doi.org/10.1590/S0036-46651993000100013 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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35 |
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89 |
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92 |
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