Immunization aganist hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 mcg) Imunização contra Hepatite B em crianças de zona endêmica: avaliação da resposta de anticorpo à vacina HB recombinante (Engerix B-20mcg)

A previous seroepidemiological study in the rural zone of Vargem Alta (ES) SouthEast of Brazil, showed a prevalence of up to 9% of hepatitis B surface antigen (HBsAg) in some areas. One hundred susceptible children aging 1 to 5 years old were selected and immunized with a recombinant DNA hepatitis B...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo
Main Authors: C.R.B. Ferreira, C.F.T. Yoshida, L.A.C. Mercadante, D.F. Gomes, J.M. Oliveira, M.S. França, M. Sidoni, I.C. Ennes, M.L. Baptista, H.G. Schatzmayr, A.M.C. Gaspar
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP) 1993
Subjects:
DNA recombinant vaccine
Immune response-children
hepatitis B recombinant vaccine
Anti-HBs
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Alta
Arctic
Boa
Sudeste
Online Access:https://doi.org/10.1590/S0036-46651993000100013
https://doaj.org/article/f0803941c706410a8a17971653cf7e13
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Summary:A previous seroepidemiological study in the rural zone of Vargem Alta (ES) SouthEast of Brazil, showed a prevalence of up to 9% of hepatitis B surface antigen (HBsAg) in some areas. One hundred susceptible children aging 1 to 5 years old were selected and immunized with a recombinant DNA hepatitis B vaccine (Smith-Kline 20 mcg) using the 0-1-6 months vaccination schedule. Blood samples were collected at the time of the first vaccine dose (month 0) in order to confirm susceptible individuals and 1,3,6 and 8 months after the first dose , to evaluate the antibody response. Our results showed that two and five months after the second dose, 79% and 88% of children seroconverted respectively, reaching 97% after the third dose. The levels of anti-HBs were calculated in milli International Units/ml (mIU/ml) and demonstrated the markedly increase of protective levels of antibodies after the third dose. These data showed a good immunogenicity of the DNA recombinant hepatitis B vaccine when administered in children of endemic areas. Um estudo soroepidemiológico prévio na zona rural de Vargem Alta (ES) - Sudeste do Brasil, mostrou uma predominância de até 9% do antígeno de superfície da Hepatite B (HBsAg). Foram selecionadas 100 crianças com faixa etária entre 1 e 5 anos de idade, as quais foram imunizadas com vacina contra Hepatite B -DNA recombinante (Smith-Kline,20 mcg) nos meses 0,1 e 6. Foram coletadas amostras de sangue antes da primeira dose da vacina (mês 0) para confirmação dos susceptíveis, e nos meses 1,3,6 e 8 após a vacinação para avaliação da resposta vacinai. Os resultados mostraram que 79 e 88% das crianças apresentaram soroconversão dois e cinco meses após a segunda dose respectivamente, atingindo 97% de soroconversão, após a 3a.dose. Os níveis de anti-HBs foram calculados em miliunidades internacionais/ml (mUI/ml), demonstrando um considerável aumento dos níveis de anticorpos protetores após a 3a. dose. Os resultados demonstraram uma boa imunogenicidade da vacina de DNA recombinante contra hepatite B, ...

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