Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

Abstract Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: McGready Rose, Muehlenbachs Atis, Lindegardh Niklas, Phyo Aung, Leimanis Mara L, Imwong Mallika, Russell Bruce, Boel Machteld E, Rijken Marcus J, Rénia Laurent, Snounou Georges, Singhasivanon Pratap, Nosten François
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2011
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/1475-2875-10-113
https://doaj.org/article/e45996e9eabd40e88eb848361ec61570
Description
Summary:Abstract Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax . This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

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