B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi.
Here, we have investigated the possible effect of B-1 cells on the activity of peritoneal macrophages in E. cuniculi infection. In the presence of B-1 cells, peritoneal macrophages had an M1 profile with showed increased phagocytic capacity and index, associated with the intense microbicidal activit...
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ftdoajarticles:oai:doaj.org/article:e065bb893afa4ef28435f078bb5635e9 2023-05-15T15:05:16+02:00 B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. Adriano Pereira Anuska Marcelino Alvares-Saraiva Fabiana Toshie de Camargo Konno Diva Denelle Spadacci-Morena Elizabeth Cristina Perez Mario Mariano Maria Anete Lallo 2019-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007674 https://doaj.org/article/e065bb893afa4ef28435f078bb5635e9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6779274?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007674 https://doaj.org/article/e065bb893afa4ef28435f078bb5635e9 PLoS Neglected Tropical Diseases, Vol 13, Iss 9, p e0007674 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007674 2022-12-31T09:54:42Z Here, we have investigated the possible effect of B-1 cells on the activity of peritoneal macrophages in E. cuniculi infection. In the presence of B-1 cells, peritoneal macrophages had an M1 profile with showed increased phagocytic capacity and index, associated with the intense microbicidal activity and a higher percentage of apoptotic death. The absence of B-1 cells was associated with a predominance of the M2 macrophages, reduced phagocytic capacity and index and microbicidal activity, increased pro-inflammatory and anti-inflammatory cytokines production, and higher percentual of necrosis death. In addition, in the M2 macrophages, spore of phagocytic E. cuniculi with polar tubular extrusion was observed, which is an important mechanism of evasion of the immune response. The results showed the importance of B-1 cells in the modulation of macrophage function against E. cuniculi infection, increasing microbicidal activity, and reducing the fungal mechanisms involved in the evasion of the immune response. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 9 e0007674 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Adriano Pereira Anuska Marcelino Alvares-Saraiva Fabiana Toshie de Camargo Konno Diva Denelle Spadacci-Morena Elizabeth Cristina Perez Mario Mariano Maria Anete Lallo B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Here, we have investigated the possible effect of B-1 cells on the activity of peritoneal macrophages in E. cuniculi infection. In the presence of B-1 cells, peritoneal macrophages had an M1 profile with showed increased phagocytic capacity and index, associated with the intense microbicidal activity and a higher percentage of apoptotic death. The absence of B-1 cells was associated with a predominance of the M2 macrophages, reduced phagocytic capacity and index and microbicidal activity, increased pro-inflammatory and anti-inflammatory cytokines production, and higher percentual of necrosis death. In addition, in the M2 macrophages, spore of phagocytic E. cuniculi with polar tubular extrusion was observed, which is an important mechanism of evasion of the immune response. The results showed the importance of B-1 cells in the modulation of macrophage function against E. cuniculi infection, increasing microbicidal activity, and reducing the fungal mechanisms involved in the evasion of the immune response. |
format |
Article in Journal/Newspaper |
author |
Adriano Pereira Anuska Marcelino Alvares-Saraiva Fabiana Toshie de Camargo Konno Diva Denelle Spadacci-Morena Elizabeth Cristina Perez Mario Mariano Maria Anete Lallo |
author_facet |
Adriano Pereira Anuska Marcelino Alvares-Saraiva Fabiana Toshie de Camargo Konno Diva Denelle Spadacci-Morena Elizabeth Cristina Perez Mario Mariano Maria Anete Lallo |
author_sort |
Adriano Pereira |
title |
B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. |
title_short |
B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. |
title_full |
B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. |
title_fullStr |
B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. |
title_full_unstemmed |
B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. |
title_sort |
b-1 cell-mediated modulation of m1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of encephalitozoon cuniculi. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007674 https://doaj.org/article/e065bb893afa4ef28435f078bb5635e9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 9, p e0007674 (2019) |
op_relation |
http://europepmc.org/articles/PMC6779274?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007674 https://doaj.org/article/e065bb893afa4ef28435f078bb5635e9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007674 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
9 |
container_start_page |
e0007674 |
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1766337003527340032 |