Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand

Highlights The regions of SURFIN1.1 were identified: SURFIN1.1 is comprised of extracellular, transmembrane (TM), and intracellular regions. Nucleotide and amino acid sequences of the extracellular region of P. falciparum SURFIN1.1 from a total of 31 field isolates were obtained and analyzed for gen...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Natpasit Chaianantakul, Tippawan Sungkapong, Jirapinya Changpad, Keawalin Thongma, Sasiwimon Sim-ut, Morakot Kaewthamasorn
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2021
Subjects:
Malaria
Plasmodium falciparum
Gene polymorphism
Variable surface antigens
SURFIN
Surf gene
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/s12936-021-03876-y
https://doaj.org/article/dfe23b4f5f3f462b9fb98e193d766cea
Description
Summary:Highlights The regions of SURFIN1.1 were identified: SURFIN1.1 is comprised of extracellular, transmembrane (TM), and intracellular regions. Nucleotide and amino acid sequences of the extracellular region of P. falciparum SURFIN1.1 from a total of 31 field isolates were obtained and analyzed for genetic polymorphism: six different haplotypes were identified. The extracellular region of the SURFIN1.1 among field isolates was conserved, especially in the cysteine-rich domain (CRD) sub-region. High polymorphism was shown in the variable region 2 (Var2), followed by N-terminal (N-ter) and variable region 1 (Var1), respectively. The findings presented herein may enable the discovery and development of a novel SURFIN-based vaccine for prevention and control of malaria.

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