Dysregulation of microRNAs may contribute to neurosensory impairment in Arctic cod (Boreogadus saida) following CO2 exposure

MicroRNAs (miRNAs) are epigenetic markers with a key role in post-transcriptional gene regulation. Several studies have described the dysregulation of miRNAs in temperature and hypoxic stress responses of marine organisms, but their role in the response to acidification conditions has remained relat...

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Bibliographic Details
Published in:Frontiers in Marine Science
Main Authors: Cara C. Schweitzer, Carolina A. Bonin, Christopher Magel, Thomas P. Hurst, Andrij Z. Horodysky
Format: Article in Journal/Newspaper
Language:English
Published: Frontiers Media S.A. 2023
Subjects:
microRNA
ocean acidification
environmental stressors
climate change
hearing loss
fish
Science
Q
General. Including nature conservation
geographical distribution
QH1-199.5
Arctic cod
Arctic
Boreogadus saida
Climate change
Ocean acidification
Online Access:https://doi.org/10.3389/fmars.2023.1247344
https://doaj.org/article/debed65411e64912bedcb5dc6299f373
Description
Summary:MicroRNAs (miRNAs) are epigenetic markers with a key role in post-transcriptional gene regulation. Several studies have described the dysregulation of miRNAs in temperature and hypoxic stress responses of marine organisms, but their role in the response to acidification conditions has remained relatively underexplored. We investigated the differential expression of miRNAs in whole brain tissue of Arctic cod (Boregogadus saida) exposed to elevated aqueous CO2 levels representative of future climate change predictions. We detected the expression of 17 miRNAs of interest that are either directly or indirectly associated with reduced auditory performance; 12 of the 17 miRNAs showed significant differential expression in high treatment vs. low (control) aqueous CO2 conditions. Target gene predictions indicated that these miRNAs are likely involved with inner ear maintenance, hair cell degradation, age-related hearing loss, neural inflammation, and injury. The highest differential expression was observed in mir-135b, which is linked with increased neural inflammation and injury that may be associated with neurosensory dysfunction. Collectively, these results elucidate the contributions of miRNA mechanisms underlying CO2-induced sensory deficits in fishes facing abiotic environmental change and suggest strong potential for this approach to yield novel insights into the mechanistic effects of climate change on marine organisms.

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