In vitro antioxidant and cytotoxic activities of essential oil of Feronia elephantum Correa

Objective: To analyse the chemical composition and evaluation of antioxidant, cytotoxic and DNA fragmentation activities of essential oil of Feronia elephantum Correa. Methods: Chemical composition analysis of hydrodistilled essential oil was determined by gas chromatography-mass spectrometry and in...

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Bibliographic Details
Published in:Asian Pacific Journal of Tropical Biomedicine
Main Authors: Ramaraj Thirugnanasampandan, Delma David
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2014
Subjects:
Feronia elephantum
Essential oil
Antioxidant
Cytotoxicity
DNA fragmentation
Arctic medicine. Tropical medicine
RC955-962
Biology (General)
QH301-705.5
Arctic
Correa
Online Access:https://doi.org/10.12980/APJTB.4.2014B878
https://doaj.org/article/dd8ae99971ce44b9ba26dd660727e5de
Description
Summary:Objective: To analyse the chemical composition and evaluation of antioxidant, cytotoxic and DNA fragmentation activities of essential oil of Feronia elephantum Correa. Methods: Chemical composition analysis of hydrodistilled essential oil was determined by gas chromatography-mass spectrometry and in vitro antioxidant activity of oil was determined by DPPH free radical, hydroxyly radical scavenging, metal chelating and prevention of deoxyribose degradation. Cytotoxicity and DNA fragmentation activities against breast cancer cells (MCF-7) were also analyzed. Results: Gas chromatography-mass spectrometry analysis revealed the presence of 24 compounds with caryophyllene oxide (62.29%) as major compound. A considerable antioxidant, cyotoxic and DNA fragmentation activities of oils was observed. Conclusions: The result of this study clearly indicates oil could be useful for food preservation and preparation.

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