Associative factors for atopic dermatitis and other atopic diseases in middle‐aged adults: A population‐based birth cohort study among 5373 subjects

Abstract Background and aims The study aimed to examine parental, longitudinal and current associative factors for atopic dermatitis (AD) and to compare those to other atopic diseases in 46‐year‐old adults. Methods Questionnaire data from the Northern Finland Birth Cohort 1966 study were used. To an...

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Bibliographic Details
Published in:Health Science Reports
Main Authors: Anna K. Haarala, Suvi‐Päivikki Sinikumpu, Jari Jokelainen, Juha Pekkanen, Laura Huilaja
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2023
Subjects:
adult
allergic conjunctivitis
allergic rhinitis
asthma
atopic dermatitis
sensitization
Medicine
R
Northern Finland
Mite
Online Access:https://doi.org/10.1002/hsr2.1015
https://doaj.org/article/da8c9ee79f6540e38854051cf69aa46f
Description
Summary:Abstract Background and aims The study aimed to examine parental, longitudinal and current associative factors for atopic dermatitis (AD) and to compare those to other atopic diseases in 46‐year‐old adults. Methods Questionnaire data from the Northern Finland Birth Cohort 1966 study were used. To analyze allergic sensitization, skin prick tests (n = 5373) were performed for birch, timothy, cat, and house dust mite at age 46. Results Maternal (odds ratio [OR] 1.81; 95% confidence interval [CI] 1.25–2.59) and paternal allergy (OR 2.54; CI 1.76–3.64), sensitization to any of the four tested aeroallergens (OR 1.56; CI 1.04–2.30) as well as polysensitization (OR 3.04; CI 2.10–4.37) were associated with current AD. Living on a farm in infancy was negatively associated with allergic rhinitis, allergic conjunctivitis, and atopic multimorbidity. Current AD (OR 2.65; CI 1.44–4.60) and all atopic diseases associated with indoor air related symptoms. Current AD associated with other atopic diseases, most strongly with allergic rhinitis (OR 4.92; CI 3.92–6.22). Conclusion Current AD in a 46‐year‐old general population occurred frequently with allergic rhinitis, allergic conjunctivitis, and asthma in the Northern Finland Birth Cohort study 1966. Parental allergy and sensitization to common aeroallergens were found as shared associative factors for AD, allergic rhinitis, allergic conjunctivitis, and asthma. AD and other atopic diseases associated with symptoms related to poor indoor air quality. In daily practice, it is important to take these comorbidities into consideration when treating patients with AD.

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