Reduction of methicillin-resistant Staphylococcus aureus biofilm growth and development using arctic berry extracts

IntroductionSurgical site infection remains a devastating and feared complication of surgery caused mainly by Staphylococcus aureus (S. aureus). More specifically, methicillin-resistant S. aureus (MRSA) infection poses a serious threat to global health. Therefore, developing new antibacterial agents...

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Bibliographic Details
Published in:Frontiers in Cellular and Infection Microbiology
Main Authors: John Jairo Aguilera-Correa, Liisa Nohynek, Hanna-Leena Alakomi, Jaime Esteban, Kirsi-Marja Oksman-Caldentey, Riitta Puupponen-Pimiä, Teemu J. Kinnari, Ramon Perez-Tanoira
Format: Article in Journal/Newspaper
Language:English
Published: Frontiers Media S.A. 2023
Subjects:
methicillin-resistant Staphylococcus aureus (MRSA)
biofilm
berry extract
surgical infection
antimicrobial
Microbiology
QR1-502
Arctic
Rubus chamaemorus
Online Access:https://doi.org/10.3389/fcimb.2023.1176755
https://doaj.org/article/da297299dc894a60bd67543fd2f718df
Description
Summary:IntroductionSurgical site infection remains a devastating and feared complication of surgery caused mainly by Staphylococcus aureus (S. aureus). More specifically, methicillin-resistant S. aureus (MRSA) infection poses a serious threat to global health. Therefore, developing new antibacterial agents to address drug resistance are urgently needed. Compounds derived from natural berries have shown a strong antimicrobial potential.MethodsThis study aimed to evaluate the effect of various extracts from two arctic berries, cloudberry (Rubus chamaemorus) and raspberry (Rubus idaeus), on the development of an MRSA biofilm and as treatment on a mature MRSA biofilm. Furthermore, we evaluated the ability of two cloudberry seed-coat fractions, hydrothermal extract and ethanol extract, and the wet-milled hydrothermal extract of a raspberry press cake to inhibit and treat biofilm development in a wound-like medium. To do so, we used a model strain and two clinical strains isolated from infected patients.ResultsAll berry extracts prevented biofilm development of the three MRSA strains, except the raspberry press cake hydrothermal extract, which produced a diminished anti-staphylococcal effect.DiscussionThe studied arctic berry extracts can be used as a treatment for a mature MRSA biofilm, however some limitations in their use exist.

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