Biochemical changes and manifestations of envenomation produced by Odonthobuthus doriae venom in rabbits

Many toxins from scorpion venoms cause neurotransmitters release by activating the autonomic system. The aim of the present work was to determine osmotic fragility of red blood cells (RBCs) and serum biochemical changes produced by the venom of Odonthobuthus doriae (O. doriae), a dangerous species o...

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Bibliographic Details
Published in:Journal of Venomous Animals and Toxins including Tropical Diseases
Main Authors: A. Z. Mirakabadi, A. Jalali, A. E. Jahromi, H. Vatanpur, A. Akbary
Format: Article in Journal/Newspaper
Language:English
Published: SciELO 2006
Subjects:
scorpion venom
Odonthobuthus doriae
biochemical changes
manifestation of envenomation
osmotic fragility of RBCs
Arctic medicine. Tropical medicine
RC955-962
Toxicology. Poisons
RA1190-1270
Zoology
QL1-991
Arctic
New Zealand
Online Access:https://doi.org/10.1590/S1678-91992006000100006
https://doaj.org/article/d9146f62723a4a3d850c43262d689fbb
Description
Summary:Many toxins from scorpion venoms cause neurotransmitters release by activating the autonomic system. The aim of the present work was to determine osmotic fragility of red blood cells (RBCs) and serum biochemical changes produced by the venom of Odonthobuthus doriae (O. doriae), a dangerous species of scorpion in Iran. For this study we selected 2 groups, each one containing 10 New Zealand white rabbits weighing 2 ± 0.2 kg. In vivo and in vitro osmotic fragilities as well as packed cell volume (PCV) were determined. Serum was separated and used for determination of glucose, blood urea nitrogen (BUN), creatinine, uric acid (UA), triglycerides, cholesterol, aspartate aminotransferase (AST, EC 2.6.1.1), and alanine aminotransferase (ALT, EC 2.6.1.2). Results indicate that Odonthobuthus doriae venom (0.5 mg/kg, IV) causes a significant increase (p<0.05) of serum glucose, UA, PCV, ALT, and AST. Increase was also observed in BUN, but it was not statistically significant. On the other hand a significant decrease (p<0.05) was observed in triglycerides and cholesterol levels. Increased in vivo osmotic fragility of RBCs was significant too, but in vitro osmotic fragility did not show a significant change. These results support the hypothesis that the biochemical variation caused by scorpion venom can be due to an autonomic storm and release of catecholamines.

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