Promotion of Wound Healing and Prevention of Frostbite Injury in Rat Skin by Exopolysaccharide from the Arctic Marine Bacterium Polaribacter sp. SM1127

Many marine microorganisms synthesize exopolysaccharides (EPSs), and some of these EPSs have been reported to have potential in different fields. However, the pharmaceutical potentials of marine EPSs are rarely reported. The EPS secreted by the Artic marine bacterium Polaribacter sp. SM1127 has good...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Mei-Ling Sun, Fang Zhao, Xiu-Lan Chen, Xi-Ying Zhang, Yu-Zhong Zhang, Xiao-Yan Song, Cai-Yun Sun, Jie Yang
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2020
Subjects:
marine bacterium sm1127
exopolysaccharides
cell migration
skin wound healing
frostbite injury prevention
Biology (General)
QH301-705.5
Arctic
Online Access:https://doi.org/10.3390/md18010048
https://doaj.org/article/d5c30fab647143b697e96f8a1f3685a4
Description
Summary:Many marine microorganisms synthesize exopolysaccharides (EPSs), and some of these EPSs have been reported to have potential in different fields. However, the pharmaceutical potentials of marine EPSs are rarely reported. The EPS secreted by the Artic marine bacterium Polaribacter sp. SM1127 has good antioxidant activity, outstanding moisture-retention ability, and considerable protective property on human dermal fibroblasts (HDFs) at low temperature. Here, the effects of SM1127 EPS on skin wound healing and frostbite injury prevention were studied. Scratch wound assay showed that SM1127 EPS could stimulate the migration of HDFs. In the full-thickness cutaneous wound experiment of Sprague−Dawley (SD) rats, SM1127 EPS increased the wound healing rate and stimulated tissue repair detected by macroscopic observation and histologic examination, showing the ability of SM1127 EPS to promote skin wound healing. In the skin frostbite experiment of SD rats, pretreatment of rat skin with SM1127 EPS increased the rate of frostbite wound healing and promoted the repair of the injured skin significantly, indicating the good effect of SM1127 EPS on frostbite injury prevention. These results suggest the promising potential of SM1127 EPS in the pharmaceutical area to promote skin wound healing and prevent frostbite injury.

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