Serum proteins and fractions, HDL-cholesterol and total IgG and IgE levels in cases of acute and chronic paracoccidioidomycosis Proteínas séricas e frações, HDL-colesterol e níveis de IgG e IgE totais na paracoccidioidomicose aguda e crônica

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Audrey de Souza Marquez, Adriana Pardini Vicentini Moreira, Paula Cesar Leonello, Fernanda Akemi Nakanishi, Eiko Nakagawa Itano
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2009
• Subjects: Imunoglobulina G; Imunoglobulina E; HDL-colesterol; Paracoccidioidomicose; Eletroforese; Enzyme-linked immunoSorbent assay; Immunoglobulin G; Immunoglobulin E; HDL-cholesterol; Paracoccidioidomycosis; Electrophoresis; Arctic medicine. Tropical medicine; RC955-962; Arctic; Aguda
• Online Access: https://doi.org/10.1590/S0037-86822009000300002; https://doaj.org/article/d5a87a6b97d24717b25cff9585fb2c2f

This study evaluated serum protein fractions, HDL-cholesterol, total immunoglobulin G and total immunoglobulin E levels in patients with acute and chronic paracoccidioidomycosis, by means of electrophoresis, enzymatic reaction and immunoenzymatic assay. The results demonstrated elevated levels of total immunoglobulin G, total immunoglobulin E, alpha-2 and gamma-globulins, which were more evident in acute than in chronic PCM, but no increase in HDL-cholesterol levels. There was a correlation between the levels of total immunoglobulin E and gamma-globulins and the alpha-2 and beta-globulin fractions in the acute form and between beta and gamma-globulins in both the acute and the chronic form. In conclusion, changes in total immunoglobulin G and immunoglobulin E levels and in the electrophoretic profile may be important markers for the prognosis and therapeutic follow-up of PCM cases, especially because protein electrophoresis is a simple laboratory test that can be applied when specific PCM serological tests are not available. In addition, levels of the gamma-globulin fraction greater than 2.0g/dl may suggest that the patient is developing a more severe form of PCM. Este trabalho avaliou as frações de proteínas séricas, HDL-colesterol e imunoglobulina G e imunoglobulina E totais em pacientes com paracoccidioidomicose aguda e crônica por eletroforese, reação enzimática e ensaio imunoenzimático. Os resultados demonstraram aumento dos níveis de imunoglobulina G e imunoglobulina E totais, alfa-2 e gama-globulinas, mais evidente na forma aguda que na forma crônica, e não nos níveis de HDL-colesterol. Houve correlação entre níveis de imunoglobulina E total e gama-globulinas e fração alfa-2 e beta-globulinas na forma aguda e entre beta e gama-globulinas nas formas aguda e crônica. Concluindo, alterações nos níveis de imunoglobulina G e imunoglobulina E totais e no perfil eletroforético podem ser importantes marcadores para prognóstico e acompanhamento terapêutico da PCM, especialmente por ser a eletroforese de proteínas ...