Schistosoma mansoni: immunodepression of hepatic schistosome granuloma formation in mice infected by Trypanosoma cruzi

• Main Authors: O. Genaro, Z. Brener, P.M.Z. Coelho
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1986
• Subjects: Schistosoma mansoni; Imunodepressão; Granuloma; Trypanosoma cruzi; Immunodepression; Arctic medicine. Tropical medicine; RC955-962; Arctic; Aguda
• Online Access: https://doaj.org/article/d4d0ab1583a248c3a752b5fb561eb5f4

Infection by Trypanosoma cruzi in mice depresses hepatic granuloma formation around Schistosoma mansoni eggs. This immunodepressive effect occurred in mice with Chagas' disease at the acute and/or chronic phases, granulomas being signijicantly smaller than those in Controls. Data suggest that Chagas ' disease depresses the delayed hypersensitivity immune response directly. A infecção de camundongos pelo Trypanosoma cruzi inibe a formação do granuloma hepático esquistossomótico. Este efeito imunodepressor ocorreu em camundongos com a fase aguda ou crônica da doença de Chagas, sendo os granulomas significativamente menores que nos animais controles. Os dados sugerem que a doença de Chagas deprime diretamente a imunidade celular.