Schistosoma mansoni: immunodepression of hepatic schistosome granuloma formation in mice infected by Trypanosoma cruzi
Infection by Trypanosoma cruzi in mice depresses hepatic granuloma formation around Schistosoma mansoni eggs. This immunodepressive effect occurred in mice with Chagas' disease at the acute and/or chronic phases, granulomas being signijicantly smaller than those in Controls. Data suggest that C...
| Main Authors: | , , |
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| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
1986
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| Subjects: | |
| Online Access: | https://doaj.org/article/d4d0ab1583a248c3a752b5fb561eb5f4 |
| Summary: | Infection by Trypanosoma cruzi in mice depresses hepatic granuloma formation around Schistosoma mansoni eggs. This immunodepressive effect occurred in mice with Chagas' disease at the acute and/or chronic phases, granulomas being signijicantly smaller than those in Controls. Data suggest that Chagas ' disease depresses the delayed hypersensitivity immune response directly. A infecção de camundongos pelo Trypanosoma cruzi inibe a formação do granuloma hepático esquistossomótico. Este efeito imunodepressor ocorreu em camundongos com a fase aguda ou crônica da doença de Chagas, sendo os granulomas significativamente menores que nos animais controles. Os dados sugerem que a doença de Chagas deprime diretamente a imunidade celular. |
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