Characterization and antimicrobial, antioxidant, and anti-proliferative activities of green synthesized magnesium oxide nanoparticles with shoot extracts of Plicosepalus curviflorus

Objective: To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus (PC-MgONPs) and evaluate the antimicrobial, antioxidant, and anti-proliferative activities of PC-MgONPs. Methods: The green synthesized PC-MgONPs were characterized by ultraviolet-visib...

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Bibliographic Details
Published in:Asian Pacific Journal of Tropical Biomedicine
Main Authors: Reem Hamoud Alrashoudi, Manal Abudawood, Ayesha Mateen, Hajera Tabassum, Noura Ibrahem Alghumlas, Sabiha Fatima, Basmah Almaarik, Farah Maqsood, Nawal M Al Musayeib, Musarat Amina
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2023
Subjects:
pc-mgonps
plicosepalus curviflorus
ftir
antimicrobial
cell viability
antioxidant
Arctic medicine. Tropical medicine
RC955-962
Biology (General)
QH301-705.5
Arctic
Online Access:https://doi.org/10.4103/2221-1691.380563
https://doaj.org/article/d3434b5c92724869a4f6b5fe6a41bcdf
Description
Summary:Objective: To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus (PC-MgONPs) and evaluate the antimicrobial, antioxidant, and anti-proliferative activities of PC-MgONPs. Methods: The green synthesized PC-MgONPs were characterized by ultraviolet-visible (UV), Fourier-transform infrared spectroscopy, zeta potential, energy dispersive X-ray, and scanning electron microscopy. Furthermore, we investigated total antioxidant capacity and antimicrobial and anti-proliferative activities using breast cancer cell lines (MDA-231). Results: The UV spectrum of PC-MgONPs showed a sharp absorption peak at 300 nm. The presence of magnesium, oxygen, and sodium was confirmed by energy dispersive X-ray analysis. Scanning electron microscopy revealed PC-MgONPs as roughly spherical granular structures with sizes ranging from 20.0 to 76.4 nm. PC-MgONPs showed considerable antimicrobial activities against Escherichia coli, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans with zones of inhibition of 11-17 mm. In addition, total antioxidant capacity and anti-proliferative activity of PC-MgONPs against MDA-231 cells were dose-dependent. Conclusions: The synthesized PC-MgONPs could be a potent antimicrobial, antioxidant and anti-cancer agent, which needs further investigation.

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