Circulation of Chikungunya virus East-Central-South Africa genotype during an outbreak in 2016-17 in Piaui State, Northeast Brazil

ABSTRACT Chikungunya virus (CHIKV) is an arbovirus that emerged in the Americas in 2013. Infection with CHIKV is symptomatic in most of the cases and patients can develop chronic arthralgia that lasts from months to years in over 40% of the cases. The East-Central-South Africa (ECSA) genotype was in...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo
Main Authors: Felipe Daniel Cardoso, Izabela Mauricio de Rezende, Emanuela Lima Teixeira Barros, Lívia Sacchetto, Tereza Cristina de Carvalho Souza Garcês, Natalia Ingrid Oliveira Silva, Pedro Augusto Alves, Jefferson Oliveira Soares, Erna Geessien Kroon, Anna Carolina Toledo da Cunha Pereira, Betânia Paiva Drumond, Gustavo Portela Ferreira
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP) 2019
Subjects:
Chikungunya virus
Brazil
ECSA genotype
Arbovirus
Togavirus
Alphavirus
Molecular surveillance
Epidemiology
E1 gene
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1590/s1678-9946201961057
https://doaj.org/article/ce77a4f0c54e4f6f848832e3d8e1694e
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Summary:ABSTRACT Chikungunya virus (CHIKV) is an arbovirus that emerged in the Americas in 2013. Infection with CHIKV is symptomatic in most of the cases and patients can develop chronic arthralgia that lasts from months to years in over 40% of the cases. The East-Central-South Africa (ECSA) genotype was introduced in Brazil in 2014, in Bahia State. Here we report the circulation of the CHIKV ECSA genotype in Piaui State, Northeast Brazil, during the years 2016-2017. The phylogenetic analysis revealed a single introduction of this lineage probably in 2015 and its maintenance at least until 2017. This analysis has also demonstrated the proximity of this genotype with isolates from neighboring States, and its partial nucleotide sequence of the viral E1 gene revealed a synapomorphy synonyms. This finding highlights the spread of the ECSA genotype in Brazil and supports its circulation in the Brazilian Northeast.

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