Refractory pemphigus foliaceus associated with herpesvirus infection: case report

ABSTRACT Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the skin. Infections caused by members of the herpesviridae family have been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not for PF. The present study aimed to investigate the pre...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo
Main Authors: Nurimar C. Fernandes, Heloisa Rampinelli, Leandro Magalhães de Souza, Maria Angélica A. M. Guimarães
Format: Article in Journal/Newspaper
Language:English
Published: Universidade de São Paulo (USP)
Subjects:
Pemphigus
Human Herpesvirus 1
Human Herpesvirus 2
Polymerase chain reaction
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1590/s1678-9946201759041
https://doaj.org/article/cc7ac14442d243d9ac847485ee876c39
Description
Summary:ABSTRACT Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the skin. Infections caused by members of the herpesviridae family have been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not for PF. The present study aimed to investigate the presence of Human herpesvirus (types 1, 2, 3) in corticosteroid refractory skin lesions from a patient with PF, by a Polymerase chain reaction (PCR) assay. The sample collected from cutaneous blisters has tested positive for herpes simplex virus type 1 (HSV1) after sequence analysis of the amplified viral genomic segment. The study concluded that when PF patients present corticosteroid or immunosuppressants refractory lesions, herpetic infection should be considered.

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