High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020

Abstract The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% conf...

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Bibliographic Details
Published in:Annals of Clinical and Translational Neurology
Main Authors: Malan Johansen, Kirsten Svenstrup, Poul Joensen, Bjarni á Steig, Guðrið Andorsdóttir, Torben Hansen, Maria Skaalum Petersen
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2022
Subjects:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Faroe Islands
Faroes
Online Access:https://doi.org/10.1002/acn3.51501
https://doaj.org/article/cb0b7ecabfd6499893dd4b4ce71c0884
Description
Summary:Abstract The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence interval [CI], 3.3–7.0) and the age‐ and sex‐standardized incidence (US 2010 Census Population) was 4.1/100,000 person‐years (95% CI, 2.7–6.0), which is a 68% increase from the 1987–2009 estimate. The 2020 crude prevalence was 9.5/100,000 (95% CI, 3.0–19.6) in a population of 52,912 inhabitants. Incidence and prevalence estimates of ALS in the Faroes are high and further research is warranted to uncover the genetic or environmental determinants of ALS in this population.

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