Anti-aging effect of sea cucumber (Cucumaria frondosa) hydrolysate on fruit flies and d-galactose-induced aging mice
The search for treatment of aging and age-related diseases is a public health issue. Sea cucumber (Cucumaria frondosa) hydrolysate (CFH) prepared by enzymatic hydrolysis and purified by ultrafiltration was examined for its peptide profile and ability to prevent and/or delay aging in fruit flies and...
| Published in: | Journal of Functional Foods |
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| Main Authors: | , , , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Elsevier
2018
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| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.jff.2018.05.033 https://doaj.org/article/c8da7cd899d84b60b98a5c314df8ddde |
| Summary: | The search for treatment of aging and age-related diseases is a public health issue. Sea cucumber (Cucumaria frondosa) hydrolysate (CFH) prepared by enzymatic hydrolysis and purified by ultrafiltration was examined for its peptide profile and ability to prevent and/or delay aging in fruit flies and age-related neurodegenerative disorders in d-galactose-induced aging mice. CFH contained peptides with low molecular weights (mainly < 3 kDa), Ala, Val and Leu at the N-terminal end and aromatic/hydrophobic/acidic amino acids in sequence. We provided the first in vivo evidence that CFH significantly prolonged the lifespan of fruit flies and ameliorated learning and memory deficits of d-galactose-induced aging mice. The mechanism underlying its protective effect might be associated with the ability to up-regulate Klotho expression, increase the activities of SOD and GSH-Px, inhibit lipid peroxidation and protein oxidation, and down-regulate acetylcholinesterase activity. CFH could be a health-promoting ingredient in coping with aging and age-related diseases. |
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