Description of a possible clonal expansion of Plasmodium vivax in Manaus - Amazonas - Brazil

Atypical P. vivax cases reported in Manaus municipality led us to detect a genetic isolate of P. vivax. Variable regions of SSUrRNA were examined from the initial time of infection and in the two recrudescences/relapses from a patient exhibiting chloroquine and primaquine resistance. A unique isolat...

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Bibliographic Details
Main Authors: Maria das Graças Costa Alecrim, Wilson Duarte Alecrim, Vanize Macêdo, Caroline T. Korves, Donald R. Roberts, Jun Li, Margery Sullivan, Thomas F. McCutchan
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1999
Subjects:
P. vivax
Clonal expansion
Resistance
Arctic medicine. Tropical medicine
RC955-962
Arctic
Online Access:https://doaj.org/article/c30c42d8bdca4ea38e274686c812bc3d
Description
Summary:Atypical P. vivax cases reported in Manaus municipality led us to detect a genetic isolate of P. vivax. Variable regions of SSUrRNA were examined from the initial time of infection and in the two recrudescences/relapses from a patient exhibiting chloroquine and primaquine resistance. A unique isolate, found at all stages of infection, suggests the presence of a clonal expansion.

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