A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control

Riboswitches contain an aptamer domain that recognizes a metabolite and an expression platform that regulates gene expression. Here the authors report the crystal structure of a preQ1-sensing riboswitch from Carnobacterium antarcticus that shows two metabolites in a single binding pocket.

Bibliographic Details
Published in:Nature Communications
Main Authors: Griffin M. Schroeder, Chapin E. Cavender, Maya E. Blau, Jermaine L. Jenkins, David H. Mathews, Joseph E. Wedekind
Format: Article in Journal/Newspaper
Language:English
Published: Nature Portfolio 2022
Subjects:
Science
Q
Antarc*
antarcticus
Online Access:https://doi.org/10.1038/s41467-021-27790-8
https://doaj.org/article/c1eaaded2e2042d0bb89dc2e7892de24
Description
Summary:Riboswitches contain an aptamer domain that recognizes a metabolite and an expression platform that regulates gene expression. Here the authors report the crystal structure of a preQ1-sensing riboswitch from Carnobacterium antarcticus that shows two metabolites in a single binding pocket.

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