Genotypes and Subtypes of Hepatitis B Virus Isolates in the Territory of Siberia

• Published in: Problems of Particularly Dangerous Infections
• Main Authors: G. V. Kochneva, V. A. Manuylov, I. G. Netesova, E. V. Chub, R. B. Bayandin, G. F. Sivolobova, A. A. Grazhdantseva, S. V. Netesov
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2011
• Subjects: genotype; sub-genotype; subtype; hbsag; hepatitis b virus; siberia; Infectious and parasitic diseases; RC109-216; nenets; Yamalo Nenets; Siberia
• Online Access: https://doi.org/10.21055/0370-1069-2011-3(109)-31-35; https://doaj.org/article/bf89265f9dc142e996b3fda5337186e8

Identified are the occurrence, serotypic and genotypic variations of Hepatitis B virus isolates (HBV) among the Novosibirsk region inhabitants (n=2000), native population of the Alarsk District of the Irkutsk Region (n=487) and Shuryshkarsk Township of the Yamalo-Nenets Autonomous District (n=657). Occurrence rate of hepatitis В surface antigen (HBsAg) among different groups of the Novosibirsk Region population varied within the limits of 3,6-35,0 %. It was 8,2 % in Alarsk District, and 3,2 % in Shuryshkarsk Township. HBV isolates of D genotype (92-97 %) prevail among the population of Siberia; few are the cases of A (1,7 %) and C (1,2-8 %) genotypes. The identified varying occurrence of HBV sub-genotypes and HBsAg subtypes in two aboriginal groups of Siberia (D3 sub-genotype and ayw2 subtype - in the Alarsk District, D2 and ayw3 - in Shuryshkarsk Township) suggests the existence of, at least, two isolated HBV virus populations, circulating among different groups of Siberia native population .