DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a norma...

Full description

Bibliographic Details
Published in:Journal of Venomous Animals and Toxins including Tropical Diseases
Main Authors: Adriana Sierra Assencio Almeida Barbosa, Larissa Ragozo Cardoso de Oliveira, Francilene Capel Tavares, Carlos Roberto Gonçalves de Lima, Suzana Madeira Diório, Sueli Aparecida Calvi, Fátima Regina Vilani-Moreno, Paulo Câmara Marques Pereira
Format: Article in Journal/Newspaper
Language:English
Published: SciELO 2015
Subjects:
Jorge Lobo’ disease
Lacazia loboi
Malnutrition
Mice
Genotoxicity
Comet assay
Arctic medicine. Tropical medicine
RC955-962
Toxicology. Poisons
RA1190-1270
Zoology
QL1-991
Arctic
Online Access:https://doi.org/10.1186/s40409-015-0006-y
https://doaj.org/article/bc7c0f6635844c83987112bdbc72b96a
Description
Summary:AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.

Similar Items