Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Rhea J Longley, Michael T White, Eizo Takashima, Masayuki Morita, Bernard N Kanoi, Connie S N Li Wai Suen, Inoni Betuela, Andrea Kuehn, Piyarat Sripoorote, Camila T Franca, Peter Siba, Leanne J Robinson, Marcus Lacerda, Jetsumon Sattabongkot, Takafumi Tsuboi, Ivo Mueller
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2017
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Pacific
• Online Access: https://doi.org/10.1371/journal.pntd.0005888; https://doaj.org/article/b90261fd6e3e4c2c915a3a58f93fc7ba

Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.