Clinical and endoscopic findings in the mucosae of the upper respiratory and digestive tracts in post-treatment follow-up of paracoccidioidomycosis patients Achados clínicos e endoscópicos na mucosa das vias aéreas e digestivas superiores no segmento pós-terapêutico de pacientes com paracoccidioidomicose

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Antonio Carlos Francesconi do Valle, Flavio Aprigliano Filho, João Soares Moreira, Bodo Wanke
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1995
• Subjects: Paracoccidioidomycosis; Treatment; Oropharyngolaryngeal lesions; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651995000500005; https://doaj.org/article/b6d07ca12a6f49cea0f8ee160404b6a0

Systematic examination of the upper respiratory and digestive tracts (URDT) was performed in a group of 80 paracoccidioidomycosis (PCM) patients submitted to post-treatment follow-up ranging from 8 months to 17 years. Mucosae of the URDT had been involved prior to specific treatment in 74 patients, distributed as follows: oropharynx, 50 (41 alone, 7 in association with the larynx, and 2 with the nasal mucosa); larynx, 30 (23 alone and 7 in association); and nasal mucosa, 3(1 alone and 2 in association). Inactive lesions were observed in all the 50 patients with lesions of the oropharynx, 3 of whom with deforming scars (1 with retraction of the tongue and 2 with narrowing of the oral orifice). One case presented a destructive lesion, with perfuration of the palate. Of the other 46 cases, examination showed nacreous white striated scars which were nearly imperceptible in some cases and in others displayed partial retraction of anatomical structures without any alteration of their features. Patients presented a high rate of missing teeth. In 3 patients with involvement of the nasal mucosa, none of whom presented active PCM lesions, 2 still had nasal voices. In 30 patients with lesions of the larynx, 1 suffered a relapse of PCM and 2 developed epidermoid carcinoma. Of the other 27 cases, none of whom had active PCM lesions, 15 presented dysphonia, 3 were tracheotomized, and 9 were asymptomatic. Foi realizado sistematicamente o exame das vias aero-digestivas superiores (VADS) em grupo de 80 pacientes de paracoccidioidomicose (PCM) acompanhados após o tratamento específico por período que variou de 8 meses a 17 anos. A mucosa das VADS estava comprometida antes do tratamento específico em 74 pacientes, assim distribuídos: orofaringe, 50 (41 isoladamente, 7 em associação com o laringe e 2 com a mucosa nasal); laringe, 30 (23 isoladamente e 7 em associação) e nasal, 3 (1 isoladamente e 2 em associação). Em todos os 50 que apresentavam lesões no orofaringe observou-se lesões inativas, 3 com cicatriz viciosa (1 com ...