Snake venom galactoside-binding lectins: a structural and functional overview

AbstractSnake venom galactoside-binding lectins (SVgalLs) comprise a class of toxins capable of recognizing and interacting with terminal galactoside residues of glycans. In the past 35 years, since the first report on the purification of thrombolectin from Bothrops atrox snake venom, several SVgalL...

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Bibliographic Details
Published in:Journal of Venomous Animals and Toxins including Tropical Diseases
Main Authors: Marco A. Sartim, Suely V. Sampaio
Format: Article in Journal/Newspaper
Language:English
Published: SciELO 2015
Subjects:
Snake venom
C-type lectin
Galactoside-binding protein
Carbohydrate recognition domain
Glycoconjugates
Inflammatory response
Antitumor activity
Bactericidal activity
Mitogenic activity
Platelet aggregation
Arctic medicine. Tropical medicine
RC955-962
Toxicology. Poisons
RA1190-1270
Zoology
QL1-991
Arctic
Online Access:https://doi.org/10.1186/s40409-015-0038-3
https://doaj.org/article/b333356089b54218a86f218cbbb18e4a
Description
Summary:AbstractSnake venom galactoside-binding lectins (SVgalLs) comprise a class of toxins capable of recognizing and interacting with terminal galactoside residues of glycans. In the past 35 years, since the first report on the purification of thrombolectin from Bothrops atrox snake venom, several SVgalLs from Viperidae and Elapidae snake families have been described, as has progressive improvement in the investigation of structural/functional aspects of these lectins. Moreover, the advances of techniques applied in protein-carbohydrate recognition have provided important approaches in order to screen for possible biological targets. The present review describes the efforts over the past 35 years to elucidate SVgalLs, highlighting their structure and carbohydrate recognition function involved in envenomation pathophysiology and potential biomedical applications.

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