Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice
Abstract Background Petroleum ether extracts of Viola websteri Hemsl (Violaceae) were reported to have anti-plasmodial activity against Plasmodium falciparum in vitro , with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA). Methods The schizontocidal activi...
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ftdoajarticles:oai:doaj.org/article:b2c5d49291254ad4a493f4a6f1341e93 2023-05-15T15:06:36+02:00 Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice Park Won-Hwan Kang Eun-Young Seo Su-Hyun Chung Ill-Min Moon Hyung-In 2009-07-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-151 https://doaj.org/article/b2c5d49291254ad4a493f4a6f1341e93 EN eng BMC http://www.malariajournal.com/content/8/1/151 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-151 1475-2875 https://doaj.org/article/b2c5d49291254ad4a493f4a6f1341e93 Malaria Journal, Vol 8, Iss 1, p 151 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-151 2022-12-31T12:09:18Z Abstract Background Petroleum ether extracts of Viola websteri Hemsl (Violaceae) were reported to have anti-plasmodial activity against Plasmodium falciparum in vitro , with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA). Methods The schizontocidal activity of 6-SA on early Plasmodium berghei infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD 50 ) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke. Results In the present study, 6-SA was found to have anti-malarial activity in vivo , when tested against P. berghei in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day). Conclusion 6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 151 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Park Won-Hwan Kang Eun-Young Seo Su-Hyun Chung Ill-Min Moon Hyung-In Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Petroleum ether extracts of Viola websteri Hemsl (Violaceae) were reported to have anti-plasmodial activity against Plasmodium falciparum in vitro , with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA). Methods The schizontocidal activity of 6-SA on early Plasmodium berghei infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD 50 ) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke. Results In the present study, 6-SA was found to have anti-malarial activity in vivo , when tested against P. berghei in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day). Conclusion 6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy. |
format |
Article in Journal/Newspaper |
author |
Park Won-Hwan Kang Eun-Young Seo Su-Hyun Chung Ill-Min Moon Hyung-In |
author_facet |
Park Won-Hwan Kang Eun-Young Seo Su-Hyun Chung Ill-Min Moon Hyung-In |
author_sort |
Park Won-Hwan |
title |
Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice |
title_short |
Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice |
title_full |
Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice |
title_fullStr |
Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice |
title_full_unstemmed |
Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice |
title_sort |
anti-malarial activity of 6-(8'z-pentadecenyl)-salicylic acid from viola websteri in mice |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-151 https://doaj.org/article/b2c5d49291254ad4a493f4a6f1341e93 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 151 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/151 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-151 1475-2875 https://doaj.org/article/b2c5d49291254ad4a493f4a6f1341e93 |
op_doi |
https://doi.org/10.1186/1475-2875-8-151 |
container_title |
Malaria Journal |
container_volume |
8 |
container_issue |
1 |
container_start_page |
151 |
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1766338169200967680 |