Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice
Abstract Background Petroleum ether extracts of Viola websteri Hemsl (Violaceae) were reported to have anti-plasmodial activity against Plasmodium falciparum in vitro , with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA). Methods The schizontocidal activi...
| Published in: | Malaria Journal |
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| Main Authors: | , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
BMC
2009
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| Subjects: | |
| Online Access: | https://doi.org/10.1186/1475-2875-8-151 https://doaj.org/article/b2c5d49291254ad4a493f4a6f1341e93 |
| Summary: | Abstract Background Petroleum ether extracts of Viola websteri Hemsl (Violaceae) were reported to have anti-plasmodial activity against Plasmodium falciparum in vitro , with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA). Methods The schizontocidal activity of 6-SA on early Plasmodium berghei infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD 50 ) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke. Results In the present study, 6-SA was found to have anti-malarial activity in vivo , when tested against P. berghei in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day). Conclusion 6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy. |
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