Features of immune reactions to short-term general cooling in practically healthy residents of Arkhangelsk, depending on the levels of cholesterol in the blood

• Published in: Obesity and metabolism
• Main Authors: V. A. Shtaborov, V. P. Patrakeeva, R. S. Alesich
• Format: Article in Journal/Newspaper
• Language: English; Russian
• Published: Endocrinology Research Centre 2024
• Subjects: сholesterol; сold temperature; immunity; Physiology; QP1-981; Biochemistry; QD415-436; Arkhangelsk
• Online Access: https://doi.org/10.14341/omet13071; https://doaj.org/article/af322db527fb4c0bbb5c4e24fb3bcec7

AIM: to identify the features of immune reactions in practically healthy individuals in response to short-term cold exposure, depending on the level of total cholesterol in the blood.MATERIALS AND METHODS: On the basis of the Laboratory of Ecological Immunology of the Institute of Physiology of Natural Adaptations of the Federal Research Center for Integrated Arctic Studies named after Academician N.P. Laverov of the Ural Branch of the Russian Academy of Sciences, 108 practically healthy women living in Arkhangelsk aged 21 to 50 years were examined. Blood was taken from the ulnar vein on an empty stomach in the morning before and immediately after general cooling for 5 minutes at a temperature of -25 °C. The complex of immunological studies included the study of venous blood hemograms: the number of platelets, erythrocytes, leukocytes, total hemoglobin in the blood, leukograms, phagocytic activity of neutrophils and blood monocytes, determination of cytokines IL-1β, IL-6, TNF-α. The study of the lipid profile included the determination of total cholesterol, glucose, triglycerides, phospholipids.RESULTS: In the Q1 group, no cases of hemoglobin deficiency were recorded, while in the Q4 group, hemoglobin deficiency was recorded in 14.29% of the surveyed, and after a short–term general cooling — in 21.43%. The total number of platelets, as well as the thrombocrit index in the Q4 group was significantly higher (259.07×10^3 cells/µl and 0.27%, respectively). The Q4 group had higher average monocyte levels in the leukocytogram (0.40±0.10×10^9 cl/l and 6.26±1.43% compared with 0.24±0.06×10^9 cl/l and 4.46±1.40%, p<0.05). It was revealed that persons from the Q1 group with higher background levels of CD4+, CD71+ lymphocytes are sensitive to short-term general cooling and whose CD4+, CD8+, CD25+, CD71+, CD56+ cells decrease by 1.3–1.6 times after visiting the cold chamber. The cytokine profile in the Q4 group was characterized by higher levels of IL-1β (7.13 pg/ml) and TNF-α (14.3 pg/ml). After short-term cold stress, ...