Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases

Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as bi...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Simon Bonte, Martine Demeunynck, Gabriela Bahrim, Ioana Otilia Ghinea, Bianca Furdui, Rodica Mihaela Dinica
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2013
Subjects:
indolizine
Candida antarctica lipase
one-pot reaction
cycloaddition
ylide
Biology (General)
QH301-705.5
Antarc*
Antarctica
Online Access:https://doi.org/10.3390/md11020431
https://doaj.org/article/ac71be70985e4d1b8f67a6f7427cd58a
Description
Summary:Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time.

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