Genetic relationships among serogroup B: serotype 4 Neisseria meningitidis strains

• Main Authors: Ana Paula S. LEMOS, Claudio T. SACCHI, Maria V. PAIVA, Teresa I. YARA, Carmo Elias A. MELLES, Leonard W. MAYER
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2001
• Subjects: Neisseria meningitidis; Serogroup B; Serotype 4; Ribotyping; Strain differentiation; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doaj.org/article/ac0684d7693d495ca42883ad967474e8

We compared the results obtained by serotyping of PorB epitopes using an expanded panel of monoclonal antibodies (mAb) including mAb 7 and mAb 10, with results obtained by RFLP of rRNA genes (ribotyping). The purpose of this study was to assess the correlation between phenotypic- and genotypic- methods for typing N. meningitidis. The ribotypes obtained using ClaI or EcoRV endonucleases grouped the strains in seven and two different patterns, respectively. This additional characterization of PorB epitopes improved the correlation between these two methods of typing N. meningitidis.