Corticosteroids for dengue - why don't they work?
Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between hig...
Published in: | PLoS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:ab87ff9fe36f4322bef11a01a29342f7 2023-05-15T15:00:09+02:00 Corticosteroids for dengue - why don't they work? Thi Hanh Tien Nguyen Than Ha Quyen Nguyen Tuan Trung Vu Jeremy Farrar Truong Long Hoang Thi Hoai Tam Dong Van Ngoc Tran Khanh Lam Phung Marcel Wolbers Stephen S Whitehead Martin L Hibberd Bridget Wills Cameron P Simmons 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002592 https://doaj.org/article/ab87ff9fe36f4322bef11a01a29342f7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3861232?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002592 https://doaj.org/article/ab87ff9fe36f4322bef11a01a29342f7 PLoS Neglected Tropical Diseases, Vol 7, Iss 12, p e2592 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002592 2022-12-30T22:07:38Z Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 12 e2592 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Thi Hanh Tien Nguyen Than Ha Quyen Nguyen Tuan Trung Vu Jeremy Farrar Truong Long Hoang Thi Hoai Tam Dong Van Ngoc Tran Khanh Lam Phung Marcel Wolbers Stephen S Whitehead Martin L Hibberd Bridget Wills Cameron P Simmons Corticosteroids for dengue - why don't they work? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. |
format |
Article in Journal/Newspaper |
author |
Thi Hanh Tien Nguyen Than Ha Quyen Nguyen Tuan Trung Vu Jeremy Farrar Truong Long Hoang Thi Hoai Tam Dong Van Ngoc Tran Khanh Lam Phung Marcel Wolbers Stephen S Whitehead Martin L Hibberd Bridget Wills Cameron P Simmons |
author_facet |
Thi Hanh Tien Nguyen Than Ha Quyen Nguyen Tuan Trung Vu Jeremy Farrar Truong Long Hoang Thi Hoai Tam Dong Van Ngoc Tran Khanh Lam Phung Marcel Wolbers Stephen S Whitehead Martin L Hibberd Bridget Wills Cameron P Simmons |
author_sort |
Thi Hanh Tien Nguyen |
title |
Corticosteroids for dengue - why don't they work? |
title_short |
Corticosteroids for dengue - why don't they work? |
title_full |
Corticosteroids for dengue - why don't they work? |
title_fullStr |
Corticosteroids for dengue - why don't they work? |
title_full_unstemmed |
Corticosteroids for dengue - why don't they work? |
title_sort |
corticosteroids for dengue - why don't they work? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002592 https://doaj.org/article/ab87ff9fe36f4322bef11a01a29342f7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 12, p e2592 (2013) |
op_relation |
http://europepmc.org/articles/PMC3861232?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002592 https://doaj.org/article/ab87ff9fe36f4322bef11a01a29342f7 |
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https://doi.org/10.1371/journal.pntd.0002592 |
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PLoS Neglected Tropical Diseases |
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7 |
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12 |
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e2592 |
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