Corticosteroids for dengue - why don't they work?

Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between hig...

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Bibliographic Details
Published in:PLoS Neglected Tropical Diseases
Main Authors: Thi Hanh Tien Nguyen, Than Ha Quyen Nguyen, Tuan Trung Vu, Jeremy Farrar, Truong Long Hoang, Thi Hoai Tam Dong, Van Ngoc Tran, Khanh Lam Phung, Marcel Wolbers, Stephen S Whitehead, Martin L Hibberd, Bridget Wills, Cameron P Simmons
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science (PLoS) 2013
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Arctic
Online Access:https://doi.org/10.1371/journal.pntd.0002592
https://doaj.org/article/ab87ff9fe36f4322bef11a01a29342f7
Description
Summary:Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.

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