Análise de receptores de quimiocinas na superfície de leucócitos circulantes de indivíduos infectados pelo Mycobacterium leprae: resultados preliminares Analysis of chemokine receptors on the surface of circulating leukocytes of individuals infected with Mycobacterium leprae: preliminary results

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Vanessa Amaral Mendonça, Gustavo Eustáquio Brito Alvim de Melo, Mauro Martins Teixeira, Olindo Assis Martins-Filho, Carlos Maurício Antunes, Antonio Lúcio Teixeira
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2008
• Subjects: Hanseníase; Receptores de quimiocina; Leucócitos; Citometria de fluxo; Leprosy; Chemokine receptors; Leukocytes; Flow cytometry; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86822008000700019; https://doaj.org/article/aa56260b726c4b819465cc2403443297

Neste estudo, a expressão de receptores de quimiocinas na superfície dos leucócitos circulantes foi feita pela citometria de fluxo. Houve aumento da porcentagem de linfócitos CCR2+CD4+ no sangue periférico dos pacientes com hanseníase. Este resultado preliminar sugeriu alteração do perfil dos receptores de quimiocinas desses pacientes. In this study, the expression of chemokine receptors on the surface of circulating leukocytes was determined using flow cytometry. An increase in the percentage of CCR2+CD4+ lymphocytes was observed in the peripheral blood of leprosy patients. This preliminary data suggests that alterations occur in the chemokine receptor profile of these patients.