ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children

Abstract Background Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (I...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Samuel Odarkwei Blankson, Danielle Seri Dadjé, Nadjla Traikia, Maroufou J. Alao, Serge Ayivi, Annick Amoussou, Philippe Deloron, Nicaise Tuikue Ndam, Jacqueline Milet, Leonardo K. Basco, Yaw Aniweh, Rachida Tahar
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2022
Subjects:
Plasmodium falciparum
Malaria
cerebral malaria
Polymorphism
ICAM-1
ICAM-1kilifi
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/s12936-022-04139-0
https://doaj.org/article/a921e6b592b143e9b4b04be79d63b91f
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Summary:Abstract Background Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (ICAM-1) as a major receptor for iRBCs binding to P. falciparum erythrocyte membrane protein 1 (PfEMP1) in the development of severe and cerebral malaria. The genetic polymorphism K29M in the immunoglobulin-like domain of ICAM-1, known as ICAM-1Kilifi, has been associated with either increased or decreased risk of developing cerebral malaria. Methods To provide more conclusive results, the genetic polymorphism of ICAM-1Kilifi was assessed by PCR and sequencing in blood samples from 215 Beninese children who presented with either mild or severe malaria including cerebral malaria. Results and conclusions The results showed that in this cohort of Beninese children, the ICAM-1kilifi variant is present at the frequencies of 0.27, similar to the frequency observed in other African countries. This ICAM-1kilifi variant was not associated with disease severity in agreement with other findings from the Gambia, Tanzania, Malawi, Gabon, and Thailand, suggesting no evidence of a direct link between this polymorphism and the pathogenesis of severe and cerebral malaria.

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