HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

Abstract INTRODUCTION: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infe...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical
Main Authors: Gemilson Soares Pontes, Hygor Halyson Figueiredo Ribeiro, Diana Mota Toro, José Pereira de Moura Neto, Victor Souza, Maria Edilene Martins de Almeida, Valdinete Alves do Nascimento, Cristovão Alves da Costa, Felipe Gomes Naveca, Mike Santos, Antonio Carlos Rosário Vallinoto
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2020
Subjects:
Prevalence
Blood transfusion
Phylogeny
HTLV-2c
Amazon region
Arctic medicine. Tropical medicine
RC955-962
Arctic
Sickle
Online Access:https://doi.org/10.1590/0037-8682-0066-2020
https://doaj.org/article/a747f4dfa8034db3952a64ee0a38e89f
Description
Summary:Abstract INTRODUCTION: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region. RESULTS: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype. CONCLUSIONS: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil’s western Amazon region.

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