Interactions between dendritic cells and CD4 + T cells during Plasmodium infection
Abstract Background During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells. Methods Using a mous...
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ftdoajarticles:oai:doaj.org/article:a72db0e6591f4020bed9bc75dbac1f66 2023-05-15T15:03:18+02:00 Interactions between dendritic cells and CD4 + T cells during Plasmodium infection Wong Kurt A Ocaña-Morgner Carlos Rodriguez Ana 2008-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-88 https://doaj.org/article/a72db0e6591f4020bed9bc75dbac1f66 EN eng BMC http://www.malariajournal.com/content/7/1/88 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-88 1475-2875 https://doaj.org/article/a72db0e6591f4020bed9bc75dbac1f66 Malaria Journal, Vol 7, Iss 1, p 88 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-88 2022-12-31T08:51:38Z Abstract Background During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells. Methods Using a mouse malaria model, the interactions of DCs and naïve CD4 + T cells have been analysed. Results DCs, either incubated in vitro with infected erythrocytes or isolated from infected mice, are able to present exogenous antigens by MHC-II, but are not able to establish prolonged effective interactions with naïve CD4 + T cells and do not induce T cell activation. It was also found that effective T cell activation of naïve CD4 + T cells is impaired during late Plasmodium yoelii infection. Conclusion These data may provide a mechanism for the lack of effective adaptive immune responses induced by the Plasmodium parasite. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 88 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Wong Kurt A Ocaña-Morgner Carlos Rodriguez Ana Interactions between dendritic cells and CD4 + T cells during Plasmodium infection |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells. Methods Using a mouse malaria model, the interactions of DCs and naïve CD4 + T cells have been analysed. Results DCs, either incubated in vitro with infected erythrocytes or isolated from infected mice, are able to present exogenous antigens by MHC-II, but are not able to establish prolonged effective interactions with naïve CD4 + T cells and do not induce T cell activation. It was also found that effective T cell activation of naïve CD4 + T cells is impaired during late Plasmodium yoelii infection. Conclusion These data may provide a mechanism for the lack of effective adaptive immune responses induced by the Plasmodium parasite. |
format |
Article in Journal/Newspaper |
author |
Wong Kurt A Ocaña-Morgner Carlos Rodriguez Ana |
author_facet |
Wong Kurt A Ocaña-Morgner Carlos Rodriguez Ana |
author_sort |
Wong Kurt A |
title |
Interactions between dendritic cells and CD4 + T cells during Plasmodium infection |
title_short |
Interactions between dendritic cells and CD4 + T cells during Plasmodium infection |
title_full |
Interactions between dendritic cells and CD4 + T cells during Plasmodium infection |
title_fullStr |
Interactions between dendritic cells and CD4 + T cells during Plasmodium infection |
title_full_unstemmed |
Interactions between dendritic cells and CD4 + T cells during Plasmodium infection |
title_sort |
interactions between dendritic cells and cd4 + t cells during plasmodium infection |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-88 https://doaj.org/article/a72db0e6591f4020bed9bc75dbac1f66 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 88 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/88 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-88 1475-2875 https://doaj.org/article/a72db0e6591f4020bed9bc75dbac1f66 |
op_doi |
https://doi.org/10.1186/1475-2875-7-88 |
container_title |
Malaria Journal |
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7 |
container_issue |
1 |
container_start_page |
88 |
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1766335162199572480 |