Interactions between dendritic cells and CD4 + T cells during Plasmodium infection
Abstract Background During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells. Methods Using a mous...
| Published in: | Malaria Journal |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
BMC
2008
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| Subjects: | |
| Online Access: | https://doi.org/10.1186/1475-2875-7-88 https://doaj.org/article/a72db0e6591f4020bed9bc75dbac1f66 |
| Summary: | Abstract Background During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells. Methods Using a mouse malaria model, the interactions of DCs and naïve CD4 + T cells have been analysed. Results DCs, either incubated in vitro with infected erythrocytes or isolated from infected mice, are able to present exogenous antigens by MHC-II, but are not able to establish prolonged effective interactions with naïve CD4 + T cells and do not induce T cell activation. It was also found that effective T cell activation of naïve CD4 + T cells is impaired during late Plasmodium yoelii infection. Conclusion These data may provide a mechanism for the lack of effective adaptive immune responses induced by the Plasmodium parasite. |
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