Lipid-metabolic risk factors of chronic non-communicable diseases among patients with gastroesophageal reflux disease

• Main Authors: A. S. Asekritova, E. S. Kylbanova
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics 2015
• Subjects: blood pressure; lipids; metabolic syndrome; gastroesophageal reflux disease; Diseases of the blood and blood-forming organs; RC633-647.5; Diseases of the circulatory (Cardiovascular) system; RC666-701; Gerd; Yakuts
• Online Access: https://doaj.org/article/a4b6d3df69fb4ff99cdc07f45d2b0c19

Lipid and metabolic risk factors for chronic noninfectious diseases for Yakuts with gastroesophageal reflux disease (GERD) and metabolic syndrome (MS) assessment work was carried out. A cross-sectional study of 140 patients with GERD was done. Depending on the MS availability and ethnicity, patients were divided into 3 groups. The main group included 50 Yakut nationality patients with GERD and MS. The comparison group I consisted of 50 Yakuts with GERD and without MS, the comparison group II consisted of 40 Russian GERD and MS. Preliminary verification of the diagnosis of GERD was done according to the Mayo Clinic and the Montreal Consensus (2006). The components of MS were determined on the basis of the recommendations of the All-Russian Scientific Society of Cardiology from 2009. Statistical processing and analysis of data was performed using the package IBM SPSS Statistics 19. Pair comparison was performed using the Mann-Whitney test. To assess the association of clinical symptoms of GERD with components of MS was used binary logistic regression method with forced inclusion of predictors. Analysis of lipid metabolic risk factors for chronic noninfectious diseases for Yakuts with gastroesophageal reflux disease and metabolic syndrome showed that sistolic and diastolic blood pressure, total cholesterol, LDL, triglycerides and the atherosclerotic index in patients with GERD and MS are characterized by high rates during normal value high density lipoprotein cholesterol. Triglyceride levels in Yakuts with MS are above recommended values, but at the same time as compared to the same period at the Russian MS were significantly lower. Assessment of the relationship of clinical symptoms of GERD with the criteria of MS in people of Yakut nationality showed the contribution of components of MS, especially abdominal obesity, high blood pressure and triglycerides, in the development of dyspeptic symptoms (bloating, heaviness in the epigastric), esophageal (epigastric burning) and extraesophageal symptoms (nocturnal cough) ...