Bioinformatics Analysis Identifies a Small ORF in the Genome of Fish Nidoviruses of Genus Oncotshavirus Predicted to Encode a Novel Integral Protein

Genome sequence analysis of Atlantic salmon bafinivirus (ASBV) revealed a small open reading frame (ORF) predicted to encode a Type I membrane protein with an N-terminal cleaved signal sequence (110 aa), likely an envelope (E) protein. Bioinformatic analyses showed that the predicted protein is stri...

Full description

Bibliographic Details
Published in:Microbiology Research
Main Authors: Frederick Kibenge, Ashley McKibbon, Molly Kibenge, Yingwei Wang
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2021
Subjects:
fish viruses
nidovirus
integral protein
envelope
Microbiology
QR1-502
Atlantic salmon
Online Access:https://doi.org/10.3390/microbiolres12040055
https://doaj.org/article/a38579507c294af2bde16075a61adbcb
Description
Summary:Genome sequence analysis of Atlantic salmon bafinivirus (ASBV) revealed a small open reading frame (ORF) predicted to encode a Type I membrane protein with an N-terminal cleaved signal sequence (110 aa), likely an envelope (E) protein. Bioinformatic analyses showed that the predicted protein is strikingly similar to the coronavirus E protein in structure. This is the first report to identify a putative E protein ORF in the genome of members of the Oncotshavirus genus (subfamily Piscavirinae, family Tobaniviridae, order Nidovirales) and, if expressed would be the third family (after Coronaviridae and Arteriviridae) within the order to have the E protein as a major structural protein.

Similar Items