The "in vitro" antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans Avaliação da atividade antifúngica do extrato etanólico de própolis G12 sobre Cryptococcus neoformans
Cryptococcosis is a worldwide disease caused by the etiological agent Cryptococcus neoformans. It affects mainly immunocompromised humans. It is relatively rare in animals only affecting those that have received prolonged antibiotic therapy. The propolis is a resin that can present several biologica...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
2007
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Subjects: | |
Online Access: | https://doi.org/10.1590/S0036-46652007000200005 https://doaj.org/article/9f81b4aee86a435d9df63ab7a00c351d |
Summary: | Cryptococcosis is a worldwide disease caused by the etiological agent Cryptococcus neoformans. It affects mainly immunocompromised humans. It is relatively rare in animals only affecting those that have received prolonged antibiotic therapy. The propolis is a resin that can present several biological properties, including antibacterial, antifungal and antiviral activities. The standard strain C. neoformans ATTC 90112 was used to the antifungal evaluation. The tests were realized with propolis ethanol extract (PEE) G12 in concentrations from 0.1 to 1.6 mg mL-1. The evaluation of MIC and MFC were done according to DUARTE (2002)5. The inhibitory effect of PEE G12 on the fungal growing was seen at the concentration of 0.2 mg mL-1 and 1.6 mg mL-1 was considered a fungicidal one. Criptococose, doença cosmopolita, causada pelo agente etiológico Cryptococcus neoformans, está associada, principalmente, a indivíduos imunocomprometidos. O acometimento de animais é relativamente raro, exceto, nos casos associados à prolongada antibioticoterapia. A própolis é uma resina que pode apresentar diversas propriedades biológicas, incluindo atividades antibacterianas, antifúngicas e antivirais. Amostra padrão de C. neoformans foi utilizada no teste de atividade antifúngica do extrato etanólico de própolis (EEP) G12 nas concentrações de 0,1 a 1,6 mg.mL-1. As avaliações da Concentração Inibitória Mínima (CIM) e Concentração Fungicida Mínima (CFM) foram realizadas conforme DUARTE5. O efeito inibitório do EEP G12 sobre o crescimento fúngico foi observado na concentração de 0,2 mg.mL-1. A concentração de 1,6 mg.mL-1 foi considerada fungicida. |
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