An updated systematic review of Zika virus-linked complications

Objective: To determine the breadth of Zika virus (ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using electronic databases ScienceDirect, Pubmed, Me...

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Bibliographic Details
Published in:Asian Pacific Journal of Tropical Medicine
Main Authors: Braira Wahid, Amjad Ali, Muhammad Waqar, Muhammad Idrees
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2018
Subjects:
zika virus
microcephaly
guillain-barre syndrome
acute myelitis
meningoencephalitis
hydrancephaly/hydrops fetalis
myasthenia gravis
Arctic medicine. Tropical medicine
RC955-962
Arctic
Prisma
Online Access:https://doi.org/10.4103/1995-7645.223527
https://doaj.org/article/9ec2f2ebff33459e9382ba391be7ace4
Description
Summary:Objective: To determine the breadth of Zika virus (ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using electronic databases ScienceDirect, Pubmed, Medline, Scopus, and Global Health Library. Only those research articles, case studies, case-control studies, case-cohort studies, cross-sectional studies, and organizational survey reports were included in the study that reported any fetal outcomes for pregnant women who had infected with ZIKV during the gestational period and ZIKV-related neurological complications in adults as well. Results: Out of total 72 retrieved articles, 50 met the inclusion criteria. We estimated a significant increase in incidence of neural abnormalities such as Guillain-Barre syndrome and microcephaly in the regions that are experiencing ZIKV outbreaks. Other neurological malformations found in ZIKV patients include hydrancephaly/hydrops fetalis, myasthenia gravis, meningoencephalitis and myelitis. Conclusion: Our systematic analysis provides the broad spectrum of neurological malformations in ZIKV infected patients and these data further support the causal link of ZIKV with neurological disorders.

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