Intermittent preventive therapy for malaria: arguments in favour of artesunate and sulphamethoxypyrazine - pyrimethamine combination
Abstract Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP) for the intermittent preventive treatment of malaria in young children (IPTi). Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethox...
Published in: | Malaria Journal |
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Main Author: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2011
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Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-10-70 https://doaj.org/article/9e0e234ce9054a3da2d25982d3786d86 |
Summary: | Abstract Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP) for the intermittent preventive treatment of malaria in young children (IPTi). Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethoxypyrazine), it is possible to manufacture fixed dose combination pills with artesunate and pyrimethamine. This combination permits a full therapy over 24 hours (dosing interval being 12 hours). It is recommended that this combination should be tested in future field studies of IPTi. |
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