The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study
Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponect...
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Karger Publishers
2016
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ftdoajarticles:oai:doaj.org/article:9deed52b78874f34bfa331ff42e6f9b9 2023-05-15T18:34:29+02:00 The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study Marit D. Solbu Jon V. Norvik Hilde M. Storhaug Bjørn O. Eriksen Toralf Melsom Anne Elise Eggen Svetlana N. Zykova Jens B. Kronborg Trond G. Jenssen 2016-09-01T00:00:00Z https://doi.org/10.1159/000447931 https://doaj.org/article/9deed52b78874f34bfa331ff42e6f9b9 EN eng Karger Publishers http://www.karger.com/Article/FullText/447931 https://doaj.org/toc/1420-4096 https://doaj.org/toc/1423-0143 1420-4096 1423-0143 doi:10.1159/000447931 https://doaj.org/article/9deed52b78874f34bfa331ff42e6f9b9 Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 623-634 (2016) Albuminuria Adiponectin Epidemiology General population Tubular damage Uric acid Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923 article 2016 ftdoajarticles https://doi.org/10.1159/000447931 2022-12-31T10:27:27Z Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ratio [ACR] and N-acetyl-β-D-glucosaminidase-creatinine ratio [NAG-CR]) in a large cohort from a general population. Methods: Three urine specimens from 7062 persons, participating in the Tromsø Study, were collected. The adjusted associations between adiponectin and SUA as independent variables, and ACR ≥1.13 mg/mmol (albuminuria) and the upper gender specific 15 percentile of NAG-CR (high NAG-CR) as dependent variables, were assessed. Results: Mean (standard deviation) age of the participants was 63.5 (9.2) years. Adiponectin was positively associated with albuminuria and high NAG-CR. SUA was associated with albuminuria (odds ratio [OR] 1.13; 95% Confidence Interval [CI] 1.05-1.21 per 59 µmol/L increase), but not with NAG-CR. There were no statistically significant interactions between SUA and adiponectin. Conclusions: Unexpectedly, adiponectin was positively associated with both urinary markers of renal damage. SUA was positively associated with albuminuria only. SUA and adiponectin added little beyond traditional cardiovascular risk factors to predict renal damage and did not interact in their associations with the urinary biomarkers. Longitudinal studies are needed before firm conclusions can be made. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Tromsø Kidney and Blood Pressure Research 41 5 623 634 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Albuminuria Adiponectin Epidemiology General population Tubular damage Uric acid Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923 |
spellingShingle |
Albuminuria Adiponectin Epidemiology General population Tubular damage Uric acid Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923 Marit D. Solbu Jon V. Norvik Hilde M. Storhaug Bjørn O. Eriksen Toralf Melsom Anne Elise Eggen Svetlana N. Zykova Jens B. Kronborg Trond G. Jenssen The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study |
topic_facet |
Albuminuria Adiponectin Epidemiology General population Tubular damage Uric acid Dermatology RL1-803 Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the genitourinary system. Urology RC870-923 |
description |
Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ratio [ACR] and N-acetyl-β-D-glucosaminidase-creatinine ratio [NAG-CR]) in a large cohort from a general population. Methods: Three urine specimens from 7062 persons, participating in the Tromsø Study, were collected. The adjusted associations between adiponectin and SUA as independent variables, and ACR ≥1.13 mg/mmol (albuminuria) and the upper gender specific 15 percentile of NAG-CR (high NAG-CR) as dependent variables, were assessed. Results: Mean (standard deviation) age of the participants was 63.5 (9.2) years. Adiponectin was positively associated with albuminuria and high NAG-CR. SUA was associated with albuminuria (odds ratio [OR] 1.13; 95% Confidence Interval [CI] 1.05-1.21 per 59 µmol/L increase), but not with NAG-CR. There were no statistically significant interactions between SUA and adiponectin. Conclusions: Unexpectedly, adiponectin was positively associated with both urinary markers of renal damage. SUA was positively associated with albuminuria only. SUA and adiponectin added little beyond traditional cardiovascular risk factors to predict renal damage and did not interact in their associations with the urinary biomarkers. Longitudinal studies are needed before firm conclusions can be made. |
format |
Article in Journal/Newspaper |
author |
Marit D. Solbu Jon V. Norvik Hilde M. Storhaug Bjørn O. Eriksen Toralf Melsom Anne Elise Eggen Svetlana N. Zykova Jens B. Kronborg Trond G. Jenssen |
author_facet |
Marit D. Solbu Jon V. Norvik Hilde M. Storhaug Bjørn O. Eriksen Toralf Melsom Anne Elise Eggen Svetlana N. Zykova Jens B. Kronborg Trond G. Jenssen |
author_sort |
Marit D. Solbu |
title |
The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study |
title_short |
The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study |
title_full |
The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study |
title_fullStr |
The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study |
title_full_unstemmed |
The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study |
title_sort |
association between adiponectin, serum uric acid and urinary markers of renal damage in the general population: cross-sectional data from the tromsø study |
publisher |
Karger Publishers |
publishDate |
2016 |
url |
https://doi.org/10.1159/000447931 https://doaj.org/article/9deed52b78874f34bfa331ff42e6f9b9 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 623-634 (2016) |
op_relation |
http://www.karger.com/Article/FullText/447931 https://doaj.org/toc/1420-4096 https://doaj.org/toc/1423-0143 1420-4096 1423-0143 doi:10.1159/000447931 https://doaj.org/article/9deed52b78874f34bfa331ff42e6f9b9 |
op_doi |
https://doi.org/10.1159/000447931 |
container_title |
Kidney and Blood Pressure Research |
container_volume |
41 |
container_issue |
5 |
container_start_page |
623 |
op_container_end_page |
634 |
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1766219242364993536 |