The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study

Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponect...

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Bibliographic Details
Published in:Kidney and Blood Pressure Research
Main Authors: Marit D. Solbu, Jon V. Norvik, Hilde M. Storhaug, Bjørn O. Eriksen, Toralf Melsom, Anne Elise Eggen, Svetlana N. Zykova, Jens B. Kronborg, Trond G. Jenssen
Format: Article in Journal/Newspaper
Language:English
Published: Karger Publishers 2016
Subjects:
Albuminuria
Adiponectin
Epidemiology
General population
Tubular damage
Uric acid
Dermatology
RL1-803
Diseases of the circulatory (Cardiovascular) system
RC666-701
Diseases of the genitourinary system. Urology
RC870-923
Tromsø
Online Access:https://doi.org/10.1159/000447931
https://doaj.org/article/9deed52b78874f34bfa331ff42e6f9b9
Description
Summary:Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ratio [ACR] and N-acetyl-β-D-glucosaminidase-creatinine ratio [NAG-CR]) in a large cohort from a general population. Methods: Three urine specimens from 7062 persons, participating in the Tromsø Study, were collected. The adjusted associations between adiponectin and SUA as independent variables, and ACR ≥1.13 mg/mmol (albuminuria) and the upper gender specific 15 percentile of NAG-CR (high NAG-CR) as dependent variables, were assessed. Results: Mean (standard deviation) age of the participants was 63.5 (9.2) years. Adiponectin was positively associated with albuminuria and high NAG-CR. SUA was associated with albuminuria (odds ratio [OR] 1.13; 95% Confidence Interval [CI] 1.05-1.21 per 59 µmol/L increase), but not with NAG-CR. There were no statistically significant interactions between SUA and adiponectin. Conclusions: Unexpectedly, adiponectin was positively associated with both urinary markers of renal damage. SUA was positively associated with albuminuria only. SUA and adiponectin added little beyond traditional cardiovascular risk factors to predict renal damage and did not interact in their associations with the urinary biomarkers. Longitudinal studies are needed before firm conclusions can be made.

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