Antibacterial Cyclic Tripeptides from Antarctica-Sponge-Derived Fungus Aspergillus insulicola HDN151418

Three new aspochracin-type cyclic tripeptides, sclerotiotides M–O ( 1 – 3 ), together with three known analogues, sclerotiotide L ( 4 ), sclerotiotide F ( 5 ), and sclerotiotide B ( 6 ), were obtained from the ethyl acetate extract of the fungus Aspergillus insulicola HDN151418, which was isolated f...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Chunxiao Sun, Ziping Zhang, Zilin Ren, Liu Yu, Huan Zhou, Yaxin Han, Mudassir Shah, Qian Che, Guojian Zhang, Dehai Li, Tianjiao Zhu
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2020
Subjects:
cyclic tripeptides
antibacterial
Antarctica sponge-derived fungus
Aspergillus insulicola
Biology (General)
QH301-705.5
Antarc*
Antarctica
Online Access:https://doi.org/10.3390/md18110532
https://doaj.org/article/9dc488a110734c26a61429a7fb1b6804
Description
Summary:Three new aspochracin-type cyclic tripeptides, sclerotiotides M–O ( 1 – 3 ), together with three known analogues, sclerotiotide L ( 4 ), sclerotiotide F ( 5 ), and sclerotiotide B ( 6 ), were obtained from the ethyl acetate extract of the fungus Aspergillus insulicola HDN151418, which was isolated from an unidentified Antarctica sponge. Spectroscopic and chemical approaches were used to elucidate their structures. The absolute configuration of the side chain in compound 4 was elucidated for the first time. Compounds 1 and 2 showed broad antimicrobial activity against a panel of pathogenic strains, including Bacillus cereus , Proteus species , Mycobacterium phlei , Bacillus subtilis , Vibrio parahemolyticus , Edwardsiella tarda , MRCNS, and MRSA, with MIC values ranging from 1.56 to 25.0 µM.

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