Dietary Oyster ( Crassostrea gigas ) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice

Previously, we have reported that the intake of oyster extract (OE), prepared from Pacific oysters ( Crassostrea gigas ), can attenuate symptoms of dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. Herein, we aimed to evaluate whether OE intake ameliorates chronic experimental...

Full description

Bibliographic Details
Published in:Foods
Main Authors: Tatsuya Ishida, Hiroyuki Matsui, Yoshikazu Matsuda, Takaki Shimono, Seiji Kanda, Toshimasa Nishiyama, Ryota Hosomi, Kenji Fukunaga, Munehiro Yoshida
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2022
Subjects:
oyster extract
Pacific oysters
Crassostrea gigas
chronic experimental colitis
microbiota
short-chain fatty acid
Chemical technology
TP1-1185
Pacific
Online Access:https://doi.org/10.3390/foods11142032
https://doaj.org/article/9a61cd60b45044d68c6799c83ef8a300
Description
Summary:Previously, we have reported that the intake of oyster extract (OE), prepared from Pacific oysters ( Crassostrea gigas ), can attenuate symptoms of dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. Herein, we aimed to evaluate whether OE intake ameliorates chronic experimental colitis induced by repeated DSS administration in mice. Male C57BL/6J (4-week-old) mice were fed either the standard diet AIN93G (control diet) or the control diet containing 5.0% ( w / w ) OE (OE diet). After 21 days of diet feeding, chronic experimental colitis was induced by three cycles of 2.0% ( w / w ) DSS solution administration (5 days), followed by distilled water (5 days). Mice fed OE alleviated the shortened colonic length, increased the relative weight of the spleen, colonic histopathological score (regeneration), and blood in the stool score compared with mice fed control diet. A tendency to improve the α-diversity of fecal microbiota, which was exacerbated by colitis, was observed in mice fed OE. Correlation analysis suggested that the anti-colitis effect of OE intake could be related to the valeric acid content and relative abundances of Ruminococcus and Enterococcus in the feces. In conclusion, OE could ameliorate DSS-induced chronic experimental colitis by improving the gut environment, including the microbiota community and SCFA composition.

Similar Items