Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-stimulated B16F10 murine melanoma cells

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Xian-Rong Zhou, Jung Hwan Oh, Fatih Karadeniz, Hyunjung Lee, Hyo Eun Kim, Migeon Jo, Youngwan Seo, Chang-Suk Kong
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2023
• Subjects: cyrtomium falcatum; melanogenesis; α-msh; b16f10 melanoma cells; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.4103/2221-1691.385571; https://doaj.org/article/98f28116f33341fc87c7bd6f8fa1c883

Objective: To explore the anti-melanogenic potential of Cyrtomium falcatum. Methods: The effects of Cyrtomium falcatum crude extract and its solvent fractions on tyrosinase activity, melanin content, and the expressions of melanogenesis-related genes and proteins were analyzed in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 cells. Results: α-MSH treatment significantly increased tyrosinase activity, and extracellular and intracellular melanin content, as well as the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase-related protein (TRP)-1, and TRP-2 in B16F10 cells. Treatment with Cyrtomium falcatum crude extract and its solvent fractions reduced tyrosinase activity and extracellular and intracellular melanin content and downregulated the expression levels of tyrosinase, MITF, TRP-1, and TRP-2 in a dose-dependent manner. Conclusions: Cyrtomium falcatum has potential anti-melanogenesis effects and can be used as a potential source material in cosmeceutical industry for the research and development of novel lead molecules with whitening properties.