The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

Abstract Background Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. Methods The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with sub...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Farfour Eric, Charlotte Frédéric, Settegrana Catherine, Miyara Makoto, Buffet Pierre
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2012
Subjects:
Malaria
Transmission
Gametocyte
Bone marrow
Plasmodium falciparum
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/1475-2875-11-285
https://doaj.org/article/9844e4db628c430284b2341bd5833205
Description
Summary:Abstract Background Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear. Methods The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria. Results A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces. Discussion and conclusion These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.

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